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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TOP2A All Species: 3.03
Human Site: S1387 Identified Species: 4.76
UniProt: P11388 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P11388 NP_001058.2 1531 174385 S1387 E A D D V K G S V P L S S S P
Chimpanzee Pan troglodytes XP_516332 1634 184611 G1434 D E Y T F S P G K S K A T P E
Rhesus Macaque Macaca mulatta XP_001092092 1620 182490 G1420 D E Y T F S P G K S K A T P E
Dog Lupus familis XP_537646 1532 174610 D1388 L D A D D A K D S V P L S P G
Cat Felis silvestris
Mouse Mus musculus Q01320 1528 172859 D1383 D L E S D V K D S V P A S P G
Rat Rattus norvegicus P41516 1526 173202 S1383 L E S D G K D S V P A S P G A
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001519680 1746 195650 T1417 E E L E H Q Q T A K A M E I Q
Chicken Gallus gallus O42130 1553 174974 P1409 S Q D P A A P P V S V P R A Q
Frog Xenopus laevis NP_001082502 1579 178601 A1402 K T E S P E N A P P K N K A V
Zebra Danio Brachydanio rerio NP_001003834 1574 177254 A1396 T K V A K A K A E K P E A S S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P15348 1447 164377 P1303 E G G S K T S P K A K K A V V
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q23670 1520 172316 P1372 R E D V V S K P K P R T G K G
Sea Urchin Strong. purpuratus XP_783546 1448 163750 K1304 D S V A L S D K P A G A K P K
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P30182 1473 164089 K1321 S A P A D S S K T A E T S K A
Baker's Yeast Sacchar. cerevisiae P06786 1428 164196 E1285 K E D K D E G E L S K I S N K
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 67.2 67.5 93.6 N.A. 89 88.7 N.A. 71.3 76.3 70.7 67.9 N.A. 51.2 N.A. 53 58.9
Protein Similarity: 100 78.6 78.4 96.4 N.A. 93.6 93.2 N.A. 79.1 85 81.8 78.8 N.A. 66.8 N.A. 70.4 73.4
P-Site Identity: 100 0 0 13.3 N.A. 6.6 40 N.A. 6.6 13.3 6.6 6.6 N.A. 6.6 N.A. 20 0
P-Site Similarity: 100 20 20 13.3 N.A. 26.6 40 N.A. 26.6 26.6 46.6 20 N.A. 13.3 N.A. 26.6 26.6
Percent
Protein Identity: N.A. N.A. N.A. 45 42.2 N.A.
Protein Similarity: N.A. N.A. N.A. 61.4 60.4 N.A.
P-Site Identity: N.A. N.A. N.A. 13.3 20 N.A.
P-Site Similarity: N.A. N.A. N.A. 20 46.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 14 7 20 7 20 0 14 7 20 14 27 14 14 14 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 27 7 27 20 27 0 14 14 0 0 0 0 0 0 0 % D
% Glu: 20 40 14 7 0 14 0 7 7 0 7 7 7 0 14 % E
% Phe: 0 0 0 0 14 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 7 7 0 7 0 14 14 0 0 7 0 7 7 20 % G
% His: 0 0 0 0 7 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 7 0 7 0 % I
% Lys: 14 7 0 7 14 14 27 14 27 14 34 7 14 14 14 % K
% Leu: 14 7 7 0 7 0 0 0 7 0 7 7 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 7 0 0 0 % M
% Asn: 0 0 0 0 0 0 7 0 0 0 0 7 0 7 0 % N
% Pro: 0 0 7 7 7 0 20 20 14 27 20 7 7 34 7 % P
% Gln: 0 7 0 0 0 7 7 0 0 0 0 0 0 0 14 % Q
% Arg: 7 0 0 0 0 0 0 0 0 0 7 0 7 0 0 % R
% Ser: 14 7 7 20 0 34 14 14 14 27 0 14 34 14 7 % S
% Thr: 7 7 0 14 0 7 0 7 7 0 0 14 14 0 0 % T
% Val: 0 0 14 7 14 7 0 0 20 14 7 0 0 7 14 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 14 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _